HER2-targeted treatments
HER2-targeted treatments have been developed specifically to work against cancer cells that produce too much of the HER2 protein.18
The HER2 protein plays an important role in how cells grow, multiply, and survive. The protein has two parts. One part is on the cell surface, and the other part is inside the cell membrane. HER2-targeted therapies block the signals from the HER2 receptor that tell the cells when to grow or produce more cells. As a result, they can slow or stop cancer growth.18
TYKERB is the first oral HER2-targeted treatment for metastatic breast cancer. TYKERB can stop the HER2 receptor from working properly. Its small size allows TYKERB to enter the cancer cell and act on HER2 from the inside.1 TYKERB, in combination with Xeloda, is FDA-approved for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 and who have received prior therapy including an anthracycline, a taxane, and Herceptin® (trastuzumab).
Other treatments for breast cancer are hormonal therapy and chemotherapy.
Ask your doctor if prescription TYKERB is right for you.
Check out GlaxoSmithKline's Tykerb® CARES support program to help patients and the healthcare providers who treat them.
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Indication
TYKERB is indicated in combination with Xeloda® (capecitabine) for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 and who have received prior therapy including an anthracycline, a taxane, and Herceptin® (trastuzumab).
Important Safety Information
Some women may develop liver damage while taking TYKERB. The cause of this damage is not known. In some cases, liver damage may be severe and may cause death. Your doctor should test your liver before and during treatment with TYKERB to check for signs of liver damage. You should contact your doctor if you have itching, yellow eyes or skin, dark urine, pain in your right upper side of your belly or feel very tired. If you develop liver damage during your treatment, your doctor may tell you to stop taking TYKERB. Before taking TYKERB, tell your doctor if you have liver problems. You may need a lower dose of TYKERB.
Before taking TYKERB, tell your doctor if you have heart problems. As with other treatments for HER2-positive advanced or metastatic breast cancer, there have been reports of changes in how the heart pumps blood through the body and how the heart beats. Call your doctor right away if you are short of breath, have rapid heartbeats (palpitations), or feel very tired.
Some people taking TYKERB have reported diarrhea. In some cases, diarrhea can be severe. Call your doctor right away if you have diarrhea. It is important to manage diarrhea with medicine as soon as it begins. Severe diarrhea may need to be treated with electrolytes and fluids given by mouth or by vein. Treatment with TYKERB may have to be delayed for a while or stopped completely.
If you have a dry cough or have shortness of breath, talk with your doctor. These may be signs of inflammation in the lungs.
Women should not become pregnant when taking TYKERB because the unborn baby may be harmed.
The most common side effects reported by patients taking TYKERB and Xeloda were diarrhea; vomiting; feeling sick to your stomach (nausea); feeling tired; red, painful hands and feet; and rash.
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines and herbal and dietary supplements.
Because TYKERB is currently indicated to be taken with another medicine called Xeloda, be sure to talk with your doctor about any medicines and supplements that should be avoided when taking Xeloda.
Please see complete US Prescribing Information for TYKERB.
Herceptin is a registered trademark of Genentech, Inc.
Xeloda is a registered trademark of Roche Laboratories Inc.
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