Prescribing Information  |  Important Safety Information  |  For Patients and Caregivers  |  Text Size A A A


Help your patients get medication and more

The Tykerb® CARES support program is sponsored by GlaxoSmithKline to help patients and the healthcare providers who treat them. All patients who are prescribed TYKERB are eligible for the Tykerb® CARES program. Download the Enrollment Form, provide the information requested, and fax the completed form to 1-866-272-9439 or call 1-866-4-TYKERB
(1-866-489-5372).



Benefits of enrolling in the Tykerb® CARES program

Treatment with TYKERB means more than medication. It also means having the assistance of Tykerb® CARES.

Key benefits for
healthcare providers 		Key benefits for patients
  • Identification of specialty pharmacies that distribute TYKERB
  • If desired, assistance with finding the specialty pharmacy with the lowest co-pay for your patients
  • One-stop source of product information
  • Assistance with reimbursement and coverage issues, including benefits verification, determination of the lowest co-pay available, benefit forecast, and alternative coverage options for eligible patients
  • Support for treatment adherence by providing key product information for your patients before they start their treatment with TYKERB

Complete a Tykerb® CARES Enrollment Form for your patients to enable them to access program services. For more information about the Tykerb® CARES Program, call 1-866-4-TYKERB (1-866-489-5372).


The following specialty pharmacies distribute TYKERB:

  • Accredo Health Group, Inc.
  • Advanced Care Scripts
  • Biologics, Inc.
  • Bioscrip®
  • Caremark
  • CuraScript
  • Diplomat
  • ivpcare
  • McKesson Specialty
  • Medmark®, a Walgreens Specialty Pharmacy
  • OncologyRx Care Advantage
  • Option Care
  • Pharmacare
  • Precision Rx
  • SpecialtyScripts
  • US Bioservices

The list of specialty pharmacies distributing TYKERB is subject to change without notice, so please continue to check this site for the most complete and up-to-date list.



Get more for your patient with
Tykerb® CARES, a support program sponsored by GlaxoSmithKline to help patients and the healthcare providers who treat them.


Learn more about HER2+ metastatic breast cancer and treatment with TYKERB.
Ask the Experts


Learn about advancements in breast cancer treatment and keep up with developments on www.TYKERB.com.


Indication

TYKERB® is indicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 and who have received prior therapy including an anthracycline, a taxane, and trastuzumab.

Dose Modification Guidelines

For dose modification guidelines, please see complete Prescribing Information.


BOXED WARNING and Additional Important Safety Information

Hepatotoxicity
TYKERB has been associated with hepatotoxicity. Hepatotoxicity (ALT or AST >3 times the upper limit of normal and total bilirubin >1.5 times the upper limit of normal) has been observed in clinical trials (<1% of patients) and postmarketing experience. The hepatotoxicity may be severe and deaths have been reported. Causality of the deaths is uncertain. The hepatotoxicity may occur days to several months after initiation of treatment. Liver function tests should be monitored before initiation of treatment, every 4 to 6 weeks during treatment, and as clinically indicated. If changes in liver function are severe, therapy with TYKERB should be discontinued and patients should not be retreated with TYKERB.

Decreased Left Ventricular Ejection Fraction
TYKERB has been reported to decrease LVEF. Caution should be taken if TYKERB is to be administered to patients with preexisting cardiac conditions, including uncontrolled or symptomatic angina, arrhythmias, or congestive heart failure. Confirm normal LVEF before starting TYKERB, and continue evaluations during treatment.

Patients with Severe Hepatic Impairment
If TYKERB is to be administered to patients with severe hepatic impairment, dose reduction should be considered.

Diarrhea
Diarrhea, including severe diarrhea, has been reported during treatment with TYKERB and was the most common adverse reaction resulting in discontinuation of TYKERB therapy. Proactive management of diarrhea with anti-diarrheal agents is important, and severe cases of diarrhea may require administration of oral or intravenous electrolytes and fluids, and interruption or discontinuation of therapy with TYKERB.

Interstitial Lung Disease/Pneumonitis
TYKERB has been associated with interstitial lung disease and pneumonitis. Patients should be monitored for pulmonary symptoms indicative of interstitial lung disease or pneumonitis and if symptoms are ≥ Grade 3 (NCI CTCAE), TYKERB should be discontinued.

QT Prolongation
TYKERB prolongs the QT interval in some patients. TYKERB should be administered with caution to patients who have or may develop prolongation of QTc. Hypokalemia or hypomagnesemia should be corrected prior to TYKERB administration. Baseline and on-treatment electrocardiograms with QT measurement should be considered.

Pregnancy
Pregnancy D
TYKERB can cause fetal harm when administered to a pregnant woman. Women should be advised not to become pregnant when taking TYKERB. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.

Adverse Reactions
The most common adverse reactions (>20%) during therapy with TYKERB plus capecitabine compared to capecitabine alone were diarrhea (65%, 40%), nausea (44%, 43%), vomiting (26%, 21%), palmar-plantar erythrodysesthesia (53%, 51%), rash (28%, 14%), and fatigue (46%, 47%).

The most common grade 3 and 4 adverse reaction (NCI CTC v3) with TYKERB plus capecitabine compared to capecitabine alone were diarrhea (14%, 10%) and palmar-plantar erythrodysesthesia (12%, 14%).


Please see full US Prescribing Information, including BOXED WARNING for TYKERB.

Xeloda is a registered trademark of Roche Laboratories Inc.
Herceptin is a registered trademark of Genentech.