This booklet may be helpful in answering your questions about treatment with TYKERB

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First Line (with Letrozole)

TYKERB is used with the medicine Femara® (letrozole) for the treatment of postmenopausal women with hormone receptor positive metastatic breast cancer that overexpresses the HER2 receptor for whom hormonal therapy is indicated. Tumors that are HER2 positive make a large amount of a protein called human epidermal growth factor receptor-2.

Second Line (with Capecitabine)

TYKERB is used with a medicine called Xeloda® (capecitabine) for the treatment of people with advanced or metastatic breast cancer whose tumors overexpress HER2, and who have received prior therapy including an anthracycline, a taxane, and Herceptin® (trastuzumab).

Important Safety Information

Some people may develop liver damage while taking TYKERB. Liver problems can be severe and deaths have happened. Before taking TYKERB, tell your doctor if you have liver problems. You may need a lower dose of TYKERB. Your doctor should do blood tests to check your liver before and during treatment with TYKERB. You should contact your doctor right away if you have itching, yellowing of your skin or the white part of your eyes, dark urine, pain or discomfort in the right upper stomach area.

Do not take TYKERB if you are allergic to any of the ingredients in TYKERB.

It is not known if TYKERB is safe and effective in children.

Before taking TYKERB, tell your doctor if you have heart problems. Some people may develop heart problems while taking TYKERB, including decreased pumping of blood from the heart and an abnormal heartbeat. Call your doctor right away if you feel like your heart is pounding or racing; if you are dizzy, tired, or light-headed; or if you are short of breath. Your doctor should check your heart before and during treatment with TYKERB.

Diarrhea is common with TYKERB and may sometimes be severe. Severe diarrhea can cause loss of fluid (dehydration) and some deaths have happened. Call your doctor right away if you have a change in bowel pattern or if you have severe diarrhea. Follow your doctor's instructions for what to do to help prevent or treat diarrhea.

If you have a cough that will not go away or are short of breath, talk with your doctor. These may be signs of lung problems.

Tell your doctor right away if you are or plan to become pregnant. You should not become pregnant when taking TYKERB because the unborn baby can be harmed. Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if TYKERB passes into breast milk. You and your doctor should decide if you will take TYKERB or breastfeed. You should not do both.

When TYKERB is taken with Xeloda or Femara, common side effects include diarrhea; red, painful hands and feet; nausea; rash; vomiting; feeling tired or weak; mouth sores; loss of appetite; indigestion; unusual hair loss or thinning; nosebleeds; headache; dry skin; itching; and nail disorders such as nail bed changes, nail pain, infection, and swelling of the cuticles.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not eat or drink grapefruit products while taking TYKERB.

Xeloda is a registered trademark of Roche Laboratories Inc.
Herceptin is a registered trademark of Genentech, Inc.
Femara is a registered trademark of Novartis Pharmaceuticals Corporation.

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